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MSRB2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9Y3D2 |
| Reactivity | Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MSRB2 |
| Epitope Specificity | 31-130/182 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Mitochondrion. |
| SIMILARITY | Belongs to the MsrB Met sulfoxide reductase family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Methionine is one of the most readily oxidized essential amino acids and an intermediate in the biosynthesis of cysteine, carnitine, taurine, lecithin, phosphatidylcholine and other phospholipids. In its oxidative state, Methionine is regulated in vivo by methionine sulfoxide reductases (Msr). MsrB2 is a 182 amino acid mitochondrial protein that is ubiquitously expressed. Belonging to the MsrB Met sulfoxide reductase family, MsrB2 acts as a catalyst for the reduction of free and protein-bound methionine sulfoxide to methionine. Upon oxidative stress, MsrB2 is suggested to play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. MsrB2 utilizes zinc ions, one per subunit, as cofactors. |
| Gene ID | 22921 |
|---|---|
| Other Names | Methionine-R-sulfoxide reductase B2, mitochondrial, MsrB2, 1.8.4.12, MSRB2, CBS-1, MSRB |
| Target/Specificity | Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | MSRB2 |
|---|---|
| Synonyms | CBS-1, MSRB |
| Function | Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance. |
| Cellular Location | Mitochondrion |
| Tissue Location | Ubiquitous. Detected in retina, ocular ciliary body, skeletal muscle, heart, colon, bone marrow, cerebellum, small intestine, fetal brain, fetal liver, kidney, spinal cord, lung, placenta and prostate. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
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$ 385.00
Cat# AP56872
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