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HSPA12A Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | O43301 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human HSPA12A |
| Epitope Specificity | 531-630/675 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SIMILARITY | Belongs to the heat shock protein 70 family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multi-protein complexes, the transportation of nascent polypeptide chains across cellular membranes and the regulation of protein folding. HSPA12A (heat shock 70kDa protein 12A) is a 675 amino acid protein that belongs to the HSP 70 family and is expressed in muscle, kidney and brain where it may play a role in cellular metabolism and regulation of neuronal function. The gene encoding HSPA12A maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria. |
| Gene ID | 259217 |
|---|---|
| Other Names | Heat shock 70 kDa protein 12A, HSPA12A, KIAA0417 |
| Target/Specificity | Widely expressed with highest levels in brain, kidney and muscle. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:200-800,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | HSPA12A |
|---|---|
| Synonyms | KIAA0417 |
| Function | Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q8K0U4}. Nucleus {ECO:0000250|UniProtKB:Q8K0U4} |
| Tissue Location | Widely expressed with highest levels in brain, kidney and muscle. |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 385.00
Cat# AP56939
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