ZCCHC4 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, ICC |
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Primary Accession | Q9H5U6 |
Reactivity | Rat, Dog, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 59010 Da |
Gene ID | 29063 |
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Other Names | rRNA N6-adenosine-methyltransferase ZCCHC4, 2.1.1.-, Zinc finger CCHC domain-containing protein 4, ZCCHC4 {ECO:0000303|PubMed:30531910, ECO:0000312|HGNC:HGNC:22917} |
Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | ZCCHC4 {ECO:0000303|PubMed:30531910, ECO:0000312|HGNC:HGNC:22917} |
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Function | rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA (PubMed:30531910, PubMed:31328227, PubMed:31799605, PubMed:31695039). N6-methylation of adenine(4220) in 28S rRNA is required for translation (PubMed:30531910, PubMed:31799605). |
Cellular Location | Nucleus, nucleolus. Cytoplasm Note=Accumulates in the nucleolus, where ribosome biogenesis takes place. |
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