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MACROD2/C20orf133 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | A1Z1Q3 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MACROD2/C20orf133 |
| Epitope Specificity | 1-100/448 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Contains 1 Macro domain. |
| SUBUNIT | Interacts with ADP-ribosylated PARP1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MACROD2 (MACRO Domain Containing 2) is a Protein Coding gene. Diseases associated with MACROD2 include autism spectrum disorder and pervasive developmental disorder. GO annotations related to this gene include hydrolase activity, acting on glycosyl bonds and deacetylase activity. An important paralog of this gene is MACROD1. |
| Gene ID | 140733 |
|---|---|
| Other Names | ADP-ribose glycohydrolase MACROD2, MACRO domain-containing protein 2, O-acetyl-ADP-ribose deacetylase MACROD2, 3.5.1.-, [Protein ADP-ribosylaspartate] hydrolase MACROD2, 3.2.2.-, [Protein ADP-ribosylglutamate] hydrolase MACROD2, 3.2.2.-, MACROD2 {ECO:0000303|PubMed:23474712, ECO:0000312|HGNC:HGNC:16126} |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | MACROD2 {ECO:0000303|PubMed:23474712, ECO:0000312|HGNC:HGNC:16126} |
|---|---|
| Function | Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). |
| Cellular Location | Nucleus. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. |
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP57174
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