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MFSD6 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | Q6ZSS7 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 88 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human MFSD6 |
| Epitope Specificity | 621-720/791 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane |
| SIMILARITY | Belongs to the major facilitator superfamily. MFSD6 family. |
| SUBUNIT | May interact with HLA-B62. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | MFSD6L is a 586 amino acid multi-pass membrane protein of the MFSD6 family and major facilitator superfamily. The gene encoding MFSD6L maps to human chromosome 17, which contains about 81 million bases and 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though it is specifically recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. |
| Gene ID | 54842 |
|---|---|
| Other Names | Major facilitator superfamily domain-containing protein 6, Macrophage MHC class I receptor 2 homolog, MFSD6, MMR2 |
| Target/Specificity | Widely expressed. Expression levels in peripheral blood mononuclear cells are highly variable between individuals, including no expression at all. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | MFSD6 |
|---|---|
| Synonyms | MMR2 |
| Cellular Location | Membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. Expression levels in peripheral blood mononuclear cells are highly variable between individuals, including no expression at all. |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP57301
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