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PGAP2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, WB, E |
|---|---|
| Primary Accession | Q9UHJ9 |
| Other Accession | Q2ABP3, Q3TQR0, Q2ABP2, NP_001138910.1 |
| Reactivity | Human |
| Predicted | Hamster, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29400 Da |
| Antigen Region | 214-242 aa |
| Gene ID | 27315 |
|---|---|
| Other Names | Post-GPI attachment to proteins factor 2, FGF receptor-activating protein 1, PGAP2, FRAG1 |
| Target/Specificity | This PGAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-242 amino acids from the C-terminal region of human PGAP2. |
| Dilution | FC~~1:10~50 WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PGAP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PGAP2 (HGNC:17893) |
|---|---|
| Synonyms | FRAG1 |
| Function | Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the second step of the fatty acid remodeling, by reacylating a lyso-GPI intermediate at sn-2 of inositol phosphate by a saturated chain (By similarity). The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts (PubMed:23561846). |
| Cellular Location | Golgi apparatus membrane {ECO:0000269|PubMed:10585768, ECO:0000269|Ref.2}; Multi-pass membrane protein |
| Tissue Location | Ubiquitously expressed, with highest levels in testis and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
PGAP2 is involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity).
References
Tashima, Y., et al. Mol. Biol. Cell 17(3):1410-1420(2006)
Lorenzi, M.V., et al. Genomics 62(1):59-66(1999)
Robertson, N.G., et al. Genomics 23(1):42-50(1994)
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