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VLDLR Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | P98155 |
| Other Accession | P35953, NP_003374.3 |
| Reactivity | Human |
| Predicted | Rabbit |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 96098 Da |
| Antigen Region | 484-510 aa |
| Gene ID | 7436 |
|---|---|
| Other Names | Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR |
| Target/Specificity | This VLDLR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-510 amino acids from the Central region of human VLDLR. |
| Dilution | WB~~1:2000 IHC-P~~1:25 FC~~1:25 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | VLDLR Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | VLDLR |
|---|---|
| Function | Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Binds also to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE- containing ligands as well as clusterin/CLU (PubMed:24381170, PubMed:30873003). In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8 (PubMed:30873003). Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (PubMed:30873003). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein Membrane, clathrin-coated pit; Single-pass type I membrane protein |
| Tissue Location | Abundant in heart and skeletal muscle; also ovary and kidney; not in liver |
Provided below are standard protocols that you may find useful for product applications.
Background
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq].
References
Sakai, K., et al. Brain Res. 1276, 11-21 (2009)
Francis, P.J., et al. J. Med. Genet. 46(5):300-307(2009)
Ananyeva, N.M., et al. Blood Coagul. Fibrinolysis 19(6):543-555(2008)
Turkmen, S., et al. Eur. J. Hum. Genet. 16(9):1070-1074(2008)
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