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SMCP Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | P49901 |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human SMCP |
| Epitope Specificity | 31-116/116 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Cytoplasm. Mitochondrion membrane. Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | SMCP is a 116 amino acid cytoplasmic protein that is found in the outer capsule that is associated with sperm mitochondria. Expressed specifically in spermatids of seminiferous tubules, SMCP is thought to be involved in the organization and stabilization of the helical sheath structure and may play a role in overall sperm motility. SMCP has a short N-terminal segment, a C-terminal lysine and several internal cysteines. Defects in the gene encoding SMCP may be a cause of male infertility due to both reduced sperm motility and an inability to pierce the zona pellucida of the female egg. |
| Gene ID | 4184 |
|---|---|
| Other Names | Sperm mitochondrial-associated cysteine-rich protein, SMCP, MCS, MCSP |
| Target/Specificity | Testis. Is selectively expressed in the spermatids of seminiferous tubules. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | SMCP |
|---|---|
| Synonyms | MCS, MCSP |
| Function | Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity). |
| Cellular Location | Cytoplasm. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. |
| Tissue Location | Testis. Is selectively expressed in the spermatids of seminiferous tubules. |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP57760
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