Glycine Receptor alpha 3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | O75311 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 53800 Da |
Gene ID | 8001 |
---|---|
Other Names | Glycine receptor subunit alpha-3, GLRA3 |
Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | GLRA3 |
---|---|
Function | Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). |
Cellular Location | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P24524}; Multi-pass membrane protein. Perikaryon {ECO:0000250|UniProtKB:P24524}. Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Synapse {ECO:0000250|UniProtKB:P24524}. Cell membrane; Multi-pass membrane protein. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO:0000250|UniProtKB:P24524} |
Tissue Location | Widely distributed throughout the central nervous system. |
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