POU2F3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, ICC |
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Primary Accession | Q9UKI9 |
Reactivity | Rat, Dog, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 47432 Da |
Gene ID | 25833 |
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Other Names | POU domain, class 2, transcription factor 3, Octamer-binding protein 11, Oct-11, Octamer-binding transcription factor 11, OTF-11, Transcription factor PLA-1, Transcription factor Skn-1, POU2F3, OTF11, PLA1 |
Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | POU2F3 (HGNC:19864) |
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Synonyms | OTF11, PLA1 |
Function | Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and regulates cell type-specific differentiation pathways. Involved in the regulation of keratinocytes differentiation (PubMed:11329378). The POU2F3-POU2AF2/POU2AF3 complex drives the expression of tuft-cell-specific genes, a rare chemosensory cells that coordinate immune and neural functions within mucosal epithelial tissues (PubMed:35576971). |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:P31362}. |
Tissue Location | Specifically expressed in epidermis and cultured keratinocytes. |
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