SLC13A2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | Q13183 |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 64410 Da |
Gene ID | 9058 |
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Other Names | Solute carrier family 13 member 2, Na(+)/dicarboxylate cotransporter 1, NaDC-1, Renal sodium/dicarboxylate cotransporter, SLC13A2, NADC1, SDCT1 |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | SLC13A2 |
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Synonyms | NADC1, SDCT1 |
Function | Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:9668069, PubMed:8967342). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:8967342, PubMed:9668069, PubMed:10894787). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity). |
Cellular Location | Apical cell membrane; Multi-pass membrane protein |
Tissue Location | Expressed in kidney and intestine (PubMed:8967342). In kidney expressed in the proximal tubule (at protein level) (PubMed:27927654). |
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