SLC17A3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | O00476 |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 46106 Da |
Gene ID | 10786 |
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Other Names | Sodium-dependent phosphate transport protein 4, Na(+)/PI cotransporter 4, Sodium/phosphate cotransporter 4, Solute carrier family 17 member 3, SLC17A3, NPT4 |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | SLC17A3 |
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Synonyms | NPT4 |
Function | [Isoform 2]: Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule (PubMed:20810651). In particular, participates in the secretion of urate from the cell into the lumen (PubMed:20810651). Urate is the end product of purine metabolism (PubMed:20810651). May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta- glucuronide, ochratoxin A, as wells as drugs such as bumetanide (PubMed:20810651). |
Cellular Location | [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
Tissue Location | Expressed in the liver and kidney (PubMed:9149941, PubMed:20810651). It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level) (PubMed:20810651) |
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