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KCNC3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q14003 |
| Reactivity | Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 80578 Da |
| Gene ID | 3748 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily C member 3, KSHIIID, Voltage-gated potassium channel subunit Kv3.3, KCNC3 |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | KCNC3 |
|---|---|
| Function | Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:22289912, PubMed:23734863, PubMed:25756792, PubMed:26997484). It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity). Required for normal motor function (PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:23734863, PubMed:25756792). Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q63959}; Multi-pass membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q63959}. Cell projection, axon {ECO:0000250|UniProtKB:Q63959}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63959}. Cell projection, dendritic spine membrane {ECO:0000250|UniProtKB:Q01956}; Multi-pass membrane protein. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Note=Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity). Detected at presynaptic calices of Held (By similarity). Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed:26997484) {ECO:0000250|UniProtKB:Q01956, ECO:0000250|UniProtKB:Q63959, ECO:0000269|PubMed:26997484} |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP58037
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