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Neurogenin 2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9H2A3 |
| Reactivity | Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 30 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Neurogenin 2 |
| Epitope Specificity | 101-200/272 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Contains 1 basic helix-loop-helix (bHLH) domain. |
| SUBUNIT | Efficient DNA binding requires dimerization with another bHLH protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Neurogenin 2 is a helix-loop-helix class of transcription factor. Transcription factors with bHLH motifs modulate critical events in the development of the mammalian neocortex. The transition from proliferation to neurogenesis involves a coordinate increase in the activity of proneural bHLH factors, including Neurogenin 2 and a decrease in the activity of Hes and Id factors. bHLH factors have key roles in corticogenesis, affecting the timing of differentiation and the specification of cell fate. |
| Gene ID | 63973 |
|---|---|
| Other Names | Neurogenin-2, NGN-2, Class A basic helix-loop-helix protein 8, bHLHa8, Protein atonal homolog 4, NEUROG2, ATOH4, BHLHA8, NGN2 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | NEUROG2 |
|---|---|
| Synonyms | ATOH4, BHLHA8, NGN2 |
| Function | Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP58092
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