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> home > Products > Primary Antibodies > Signal Transduction > Steroid sulfatase Polyclonal Antibody
Steroid sulfatase Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
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- BACKGROUND
Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | P08842 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 62 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human Steroid sulfatase |
| Epitope Specificity | 51-150/583 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Endoplasmic reticulum membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the sulfatase family. |
| SUBUNIT | Homodimer. |
| Post-translational modifications | The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| DISEASE | Defects in STS are the cause of ichthyosis X-linked (IXL) [MIM:308100]. Ichthyosis X-linked is a keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). [provided by RefSeq, Jul 2008]. |
| Gene ID | 412 |
|---|---|
| Other Names | Steryl-sulfatase, 3.1.6.2, Arylsulfatase C, ASC, Estrone sulfatase, Steroid sulfatase, Steryl-sulfate sulfohydrolase, STS, ARSC1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | STS |
|---|---|
| Synonyms | ARSC1 |
| Function | Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid. |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, microneme membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP58101
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