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LANCL2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9NS86 |
| Reactivity | Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human LANCL2 |
| Epitope Specificity | 331-430/460 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. Cytoplasm. Cell membrane. Note=Localizes to the juxta-nuclear vesicles. Associates with the cortical actin cytoskeleton. Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo. Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin). |
| SIMILARITY | Belongs to the LanC-like protein family. |
| SUBUNIT | Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P). PIP-binding enhances membrane association. |
| Post-translational modifications | Myristoylated. Essential for membrane association. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | bs-5765P is one synthetic peptide derived from human LANCL2. LANCL2 belongs to the LanC like protein family. It is expressed in the brain and testis. LANCL2 is a bystander gene coamplified and overexpressed with epidermal growth factor receptor (EGFR) in 20% of all glioblastomas. Its exogenous expression in a sarcoma cell line decreases the expression of ABCB1 (P glycoprotein 1) and increases cellular sensitivity to an anticancer drug (adriamycin). |
| Gene ID | 55915 |
|---|---|
| Other Names | LanC-like protein 2, Testis-specific adriamycin sensitivity protein, LANCL2, GPR69B, TASP |
| Target/Specificity | Expressed in brain and testis. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | LANCL2 |
|---|---|
| Synonyms | GPR69B, TASP |
| Function | Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. |
| Cellular Location | Nucleus. Cytoplasm. Cell membrane Note=Localizes to the juxta-nuclear vesicles (PubMed:16979580) Associates with the cortical actin cytoskeleton (PubMed:16979580) Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane- association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580) |
| Tissue Location | Expressed in brain and testis. |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP58308
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