ST3GAL5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
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Primary Accession | Q9UNP4 |
Other Accession | NP_003887.3, NP_001035902.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 47990 Da |
Antigen Region | 389-418 aa |
Gene ID | 8869 |
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Other Names | Lactosylceramide alpha-2, 3-sialyltransferase, CMP-NeuAc:lactosylceramide alpha-2, 3-sialyltransferase, Ganglioside GM3 synthase, ST3Gal V, ST3GalV, Sialyltransferase 9, ST3GAL5, SIAT9 |
Target/Specificity | This ST3GAL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-418 amino acids of human ST3GAL5. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ST3GAL5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ST3GAL5 |
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Synonyms | SIAT9 |
Function | Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis) (PubMed:9822625, PubMed:16934889). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D- galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)- Cer (LacCer) (PubMed:16934889). |
Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
Tissue Location | Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis. mRNA widely distributed in human brain, but slightly elevated expression was observed in the cerebral cortex, temporal lobe, and putamen. |
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