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PMCA2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q01814 |
| Reactivity | Rat, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 136876 Da |
| Gene ID | 491 |
|---|---|
| Other Names | Plasma membrane calcium-transporting ATPase 2, PMCA2, 7.2.2.10, Plasma membrane calcium ATPase isoform 2, Plasma membrane calcium pump isoform 2, ATP2B2, PMCA2 |
| Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | ATP2B2 {ECO:0000303|PubMed:15829536, ECO:0000312|HGNC:HGNC:815} |
|---|---|
| Function | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:17234811, PubMed:15829536). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:17234811, PubMed:15829536). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:17234811, PubMed:15829536). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:17234811, PubMed:15829536). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Synapse {ECO:0000250|UniProtKB:Q9R0K7} [Isoform WB]: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein [Isoform ZA]: Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle |
Research Areas
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Application Protocols
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$ 350.00
Cat# AP58452
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