MRGX1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF, ICC |
---|---|
Primary Accession | Q96LB2 |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 36250 Da |
Gene ID | 259249 |
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Other Names | Mas-related G-protein coupled receptor member X1, Sensory neuron-specific G-protein coupled receptor 3/4, MRGPRX1, MRGX1, SNSR3, SNSR4 |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | MRGPRX1 |
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Synonyms | MRGX1, SNSR3, SNSR4 |
Function | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine- independent manner. |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. |
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