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TMUB1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q9BVT8 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 26 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human TMUB1 |
| Epitope Specificity | 101-200/246 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Multi-pass membrane protein (Potential). Cytoplasm. Nucleus. Note=Predominantly nuclear during growth arrest (By similarity). Actively exported from the nucleus in dividing cells. |
| SIMILARITY | Contains 1 ubiquitin-like domain. |
| SUBUNIT | Interacts with EEF1A1 (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation. |
| Gene ID | 83590 |
|---|---|
| Other Names | Transmembrane and ubiquitin-like domain-containing protein 1, Dendritic cell-derived ubiquitin-like protein, DULP, Hepatocyte odd protein shuttling protein, Ubiquitin-like protein SB144, iHOPS, TMUB1, C7orf21, DULP, HOPS |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | TMUB1 |
|---|---|
| Synonyms | C7orf21, DULP, HOPS |
| Function | Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as a negative regulator of hepatocyte growth during regeneration (By similarity). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q9JMG3}; Multi- pass membrane protein {ECO:0000250|UniProtKB:Q9JMG3}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JMG3}. Recycling endosome {ECO:0000250|UniProtKB:Q53AQ4}. Cytoplasm {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3} Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3} |
| Tissue Location | Ubiquitously expressed with highest levels in mammary and thyroid glands, bone marrow and spleen; limited expression in cardiac, pancreatic and ovarian tissues |
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP58704
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