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NGFRAP1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q00994 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 13 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human NADE/NGFRAP1 |
| Epitope Specificity | 34-111/111 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. Cytoplasm. Note=Shuttles betweenthe cytoplasm and the nucleus. Associates with replicatingmitochondria (By similarity). |
| SIMILARITY | Belongs to the BEX family. |
| SUBUNIT | Self-associates. Interacts with 14-3-3 epsilon (YWHAE).Interacts with DIABLO/SMAC (By similarity). Binds to the DEATHdomain of p75NTR/NGFR. |
| Post-translational modifications | Ubiquitinated. Degraded by the proteasome (By similarity). |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role in the pathogenesis of neurogenetic diseases. Tissue specificity: Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver. |
| Gene ID | 27018 |
|---|---|
| Other Names | Protein BEX3, Brain-expressed X-linked protein 3 {ECO:0000312|HGNC:HGNC:13388}, Nerve growth factor receptor-associated protein 1, Ovarian granulosa cell 13.0 kDa protein HGR74, p75NTR-associated cell death executor, BEX3 (HGNC:13388), DXS6984E, NADE, NGFRAP1 |
| Target/Specificity | Found in ovarian granulosa cells, testis,prostate and seminal vesicle tissue. High levels also detected inliver. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | BEX3 (HGNC:13388) |
|---|---|
| Synonyms | DXS6984E, NADE, NGFRAP1 |
| Function | May be a signaling adapter molecule involved in NGFR/p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates. |
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q9WTZ9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9WTZ9}. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria. {ECO:0000250|UniProtKB:Q9WTZ9} |
| Tissue Location | Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP58707
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