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CCDC11 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q96M91 |
| Reactivity | Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61835 Da |
| Gene ID | 220136 |
|---|---|
| Other Names | Cilia- and flagella-associated protein 53 {ECO:0000312|HGNC:HGNC:26530}, Coiled-coil domain-containing protein 11 {ECO:0000312|HGNC:HGNC:26530}, CFAP53 (HGNC:26530) |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | CFAP53 (HGNC:26530) |
|---|---|
| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Regulates motility patterns of both 9+0 and 9+2 motile cilia through differential localization and recruitment of axonemal dynein components (By similarity). Required for centriolar satellite integrity and non-motile cilium assembly (PubMed:26538025). Required for motile cilium formation (PubMed:26538025). Through its role in the beating of primary cilia, involved in the establishment of organ laterality during embryogenesis (PubMed:26531781). Required for sperm flagellum biogenesis and is essential for male fertility (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9D439} Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton. Cell projection, cilium. Note=In tracheal cell cilia, localizes prominently to both centriolar satellites and axonemes (By similarity) Tightly associated with microtubules in tracheal cilia (By similarity) In embryonic node cells, localizes to the base of the node cilia at the centriolar satellites and, to a lesser extent, to the cilium axoneme (By similarity). Localizes to centriolar satellites through G1, S phase, G2 and mitosis (PubMed:26538025). Enriched on the spindle poles in mitosis (PubMed:26538025). Relocalizes from the centriolar satellite to the ciliary transition zone upon ciliogenesis (PubMed:26538025). In skin fibroblast cells, locates predominantly to the centriole with much lower levels associated with the actin cytoskeleton (PubMed:28621423) Localizes to the sperm flagellum and manchette (By similarity) {ECO:0000250|UniProtKB:Q9D439, ECO:0000269|PubMed:26538025, ECO:0000269|PubMed:28621423} |
| Tissue Location | Expressed in skin fibroblasts (at protein level) (PubMed:22577226, PubMed:28621423). Expressed in nasal respiratory epithelial cells (at protein level) (PubMed:25504577). Expressed in airway epithelial cells (PubMed:36191189) |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP58741
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