BEX4 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF |
---|---|
Primary Accession | Q9NWD9 |
Reactivity | Rat, Pig, Dog |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 14067 Da |
Gene ID | 56271 |
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Other Names | Protein BEX4, BEX1-like protein 1 {ECO:0000312|HGNC:HGNC:25475}, Brain-expressed X-linked protein 4 {ECO:0000303|PubMed:15958283, ECO:0000312|HGNC:HGNC:25475}, Nerve growth factor receptor-associated protein 3, BEX4 {ECO:0000303|PubMed:15958283, ECO:0000312|HGNC:HGNC:25475} |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | BEX4 {ECO:0000303|PubMed:15958283, ECO:0000312|HGNC:HGNC:25475} |
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Function | May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (PubMed:27512957). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). |
Cellular Location | Cytoplasm, cytoskeleton, spindle pole. Nucleus Cytoplasm. Note=Also localizes to microtubules. |
Tissue Location | Very high expression in heart, skeletal muscle, liver, and kidney. The levels of expression are uniform throughout the brain. |
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