FAM150A Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, IHC-F, IF |
---|---|
Primary Accession | Q6UXT8 |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 14269 Da |
Gene ID | 389658 |
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Other Names | ALK and LTK ligand 1 {ECO:0000312|HGNC:HGNC:33775}, Augmentor beta, AUG-beta, Protein FAM150A, ALKAL1 (HGNC:33775), FAM150A |
Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | ALKL1 |
---|---|
Function | Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation (PubMed:25331893, PubMed:26418745, PubMed:26630010, PubMed:34646012, PubMed:34819673). Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation (PubMed:34646012, PubMed:34819673). In contrast to ALKAL2, does not act as a potent physiological ligand for ALK (PubMed:26418745, PubMed:34646012). |
Cellular Location | Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell membrane. Note=Following interaction with receptor tyrosine kinase LTK, associates with the cell membrane, membrane-binding is required to activate LTK {ECO:0000250|UniProtKB:Q6UX46} |
Tissue Location | Widely expressed with highest levels in thyroid and moderate levels in stomach, trachea, small intestine, prostate and brain. |
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