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DPY19L2 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q6NUT2 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 87 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human DPY19L2 |
| Epitope Specificity | 101-200/758 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Involvement in disease：Defects in DPY19L2 are a cause of globozoospermia (GLOBZOOS) . An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome. In the most severe cases the acrosome is totally absent. Globozoospermia is also characterized by abnormal nuclear shape as well as abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of GLOBZOOS. |
| SIMILARITY | Belongs to the dpy-19 family. |
| SUBUNIT | Membrane; Multi-pass membrane protein (Potential). |
| DISEASE | Defects in DPY19L2 are the cause of spermatogenic failure type 9 (SPGF9) [MIM:613958]. An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of SPGF9. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011] |
| Gene ID | 283417 |
|---|---|
| Other Names | Probable C-mannosyltransferase DPY19L2, 2.4.1.-, Dpy-19-like protein 2, Protein dpy-19 homolog 2, DPY19L2 |
| Target/Specificity | Widely expressed with high expression in testis. |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | DPY19L2 (HGNC:19414) |
|---|---|
| Function | Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. |
| Cellular Location | Nucleus inner membrane {ECO:0000250|UniProtKB:P0CW70}; Multi-pass membrane protein. Note=Colocalizes with DPY19L2 at the inner nuclear membrane. {ECO:0000250|UniProtKB:P0CW70} |
| Tissue Location | Widely expressed with high expression in testis. Not detectable in ejaculated sperm (at protein level) |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP58954
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