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UNC93B Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9H1C4 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 66631 Da |
| Gene ID | 81622 |
|---|---|
| Other Names | Protein unc-93 homolog B1, Unc-93B1, hUNC93B1, UNC93B1, UNC93, UNC93B |
| Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | UNC93B1 (HGNC:13481) |
|---|---|
| Synonyms | UNC93, UNC93B |
| Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Endosome Lysosome. Cytoplasmic vesicle, phagosome Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides (By similarity) Colocalizes with LAMP5 in large endosomal intracellular vesicles {ECO:0000250, ECO:0000269|PubMed:18082565, ECO:0000269|PubMed:21642595} |
| Tissue Location | Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP59022
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