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KPNA1 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, IHC-F, IF, ICC |
|---|---|
| Primary Accession | P52294 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60222 Da |
| Gene ID | 3836 |
|---|---|
| Other Names | Importin subunit alpha-5, Karyopherin subunit alpha-1, Nucleoprotein interactor 1, NPI-1, RAG cohort protein 2, SRP1-beta, Importin subunit alpha-5, N-terminally processed, KPNA1, RCH2 |
| Dilution | Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC=1:100-500, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | KPNA1 |
|---|---|
| Synonyms | RCH2 |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:7892216, PubMed:8692858, PubMed:27713473). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:7892216, PubMed:8692858, PubMed:27713473). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7892216, PubMed:27713473). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed ubiquitously. |
Research Areas
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$ 350.00
Cat# AP59090
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