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RNF167 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-F, IF, E |
|---|---|
| Primary Accession | Q9H6Y7 |
| Reactivity | Rat, Pig, Dog, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 36 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human RNF167 |
| Epitope Specificity | 201-300/350 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Endomembrane system. Targeted to cytoplasmic membranes. |
| SIMILARITY | Contains 1 PA (protease associated) domain. Contains 1 RING-type zinc finger. |
| SUBUNIT | Interacts with SLC22A18. |
| Post-translational modifications | Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition. |
| Gene ID | 26001 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase RNF167, 2.3.2.27, RING finger protein 167, RING-type E3 ubiquitin transferase RNF167, RING105, RNF167 |
| Target/Specificity | Strongly expressed in the kidney and liver (at protein level). |
| Dilution | IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | RNF167 {ECO:0000303|PubMed:23353890, ECO:0000312|HGNC:HGNC:24544} |
|---|---|
| Function | E3 ubiquitin-protein ligase that acts as a regulator of the TORC1 signaling pathway (PubMed:33594058, PubMed:35114100). Positively regulates the TORC1 signaling pathway independently of arginine levels: acts by catalyzing 'Lys-29'-polyubiquitination and degradation of CASTOR1, releasing the GATOR2 complex from CASTOR1 (PubMed:33594058). Also negatively regulates the TORC1 signaling pathway in response to leucine deprivation: acts by mediating 'Lys-63'-linked polyubiquitination of SESN2, promoting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Also involved in protein trafficking and localization (PubMed:23129617, PubMed:23353890, PubMed:24387786, PubMed:27808481, PubMed:32409562). Acts as a regulator of synaptic transmission by mediating ubiquitination and degradation of AMPAR receptor GluA2/GRIA2 (PubMed:23129617, PubMed:33650289). Does not catalyze ubiquitination of GluA1/GRIA1 (PubMed:23129617). Also acts as a regulator of the recycling endosome pathway by mediating ubiquitination of VAMP3 (PubMed:23353890). Regulates lysosome positioning by catalyzing ubiquitination and degradation of ARL8B (PubMed:27808481). Plays a role in growth regulation involved in G1/S transition by mediating, possibly by mediating ubiquitination of SLC22A18 (PubMed:16314844). Acts with a limited set of E2 enzymes, such as UBE2D1 and UBE2N (PubMed:33650289). |
| Cellular Location | Lysosome membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Targeted to cytoplasmic membranes; mainly localizes to lysosomal membrane (PubMed:16314844, PubMed:23129617). A subpopulation localizes to the cell membrane of neurons (PubMed:23129617). [Isoform 2]: Cytoplasm, cytosol |
| Tissue Location | Widely expressed (PubMed:23129617). Strongly expressed in the kidney, pancreas, testis and liver (at protein level) (PubMed:16314844, PubMed:23129617). |
Research Areas
Citations (0)
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Application Protocols
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$ 385.00
Cat# AP59189
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