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> home > Products > Primary Antibodies > Cardiovascular > Transcription factor 25 Polyclonal Antibody
Transcription factor 25 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF, ICC, E |
|---|---|
| Primary Accession | Q9BQ70 |
| Reactivity | Rat, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 76667 Da |
| Gene ID | 22980 |
|---|---|
| Other Names | Transcription factor 25, TCF-25, Nuclear localized protein 1, TCF25, KIAA1049, NULP1 |
| Dilution | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC=1:100-500,IF=1:100-500,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | TCF25 {ECO:0000303|PubMed:30244831, ECO:0000312|HGNC:HGNC:29181} |
|---|---|
| Function | Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). |
| Cellular Location | Nucleus. Cytoplasm, cytosol. Note=Mainly nuclear |
| Tissue Location | In the embryo, widely expressed with highest levels in brain (PubMed:16574069). In the adult, highest expression is found in the heart (PubMed:16574069, PubMed:32805187). Repressed in cardiac tissue of patients with heart failure (at protein level) (PubMed:32805187). mRNA levels in the heart are unchanged in patients with heart failure (PubMed:32805187). |
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Application Protocols
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$ 385.00
Cat# AP59302
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