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ANKRD32 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-F, IF |
|---|---|
| Primary Accession | Q9BQI6 |
| Reactivity | Rat, Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 121050 Da |
| Gene ID | 84250 |
|---|---|
| Other Names | SMC5-SMC6 complex localization factor protein 1 {ECO:0000312|HGNC:HGNC:25408}, Ankyrin repeat domain-containing protein 32, BRCT domain-containing protein 1, Smc5/6 localization factor 1, SLF1 {ECO:0000303|PubMed:25931565, ECO:0000312|HGNC:HGNC:25408} |
| Dilution | Elisa=1:500-1000,IHC-F=1:100-500,IF=1:50-200, |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | SLF1 {ECO:0000303|PubMed:25931565, ECO:0000312|HGNC:HGNC:25408} |
|---|---|
| Function | Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565, PubMed:36373674). |
| Cellular Location | Nucleus. Cytoplasm {ECO:0000250|UniProtKB:Q8R3P9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8R3P9} Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage Colocalizes with RAD18 in the nucleus and to centrosomes (By similarity). Associates with chromatin (PubMed:25931565). Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565) {ECO:0000250|UniProtKB:Q8R3P9, ECO:0000269|PubMed:25931565} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 350.00
Cat# AP59374
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