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C2orf18 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| IHC-P, IHC-F, IF, E |
|---|---|
| Primary Accession | Q8N357 |
| Reactivity | Rat, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38 KDa |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human C2orf18/ANT2BP |
| Epitope Specificity | 231-330/371 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Mitochondrion. Lysosome membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the SLC35F solute transporter family. Contains 1 EamA domain. |
| SUBUNIT | Interacts with SLC25A5. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | C2orf18 is a 371 amino acid multi-pass membrane protein that contains one DUF6 domain and is encoded by a gene that maps to human chromosome 2p23.3. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr鰉 syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes. |
| Gene ID | 54978 |
|---|---|
| Other Names | Solute carrier family 35 member F6, ANT2-binding protein, ANT2BP, Transport and Golgi organization 9 homolog, SLC35F6, C2orf18 |
| Target/Specificity | Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid. Weakly expressed in lung, heart, liver and kidney. |
| Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,ELISA=1:5000-10000 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | SLC35F6 |
|---|---|
| Synonyms | C2orf18 |
| Function | Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter. |
| Cellular Location | Mitochondrion. Lysosome membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in pancreatic ductal adenocarcinoma (PDAC) (at protein level). Strongly expressed in prostate and thyroid Weakly expressed in lung, heart, liver and kidney |
Research Areas
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Application Protocols
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$ 385.00
Cat# AP59387
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