C2ORF25 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, IHC-F, IF, IEM |
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Primary Accession | Q9H3L0 |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 32940 Da |
Gene ID | 27249 |
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Other Names | Cobalamin trafficking protein CblD, CblD, Methylmalonic aciduria and homocystinuria type D protein, mitochondrial, MMADHC (HGNC:25221), C2orf25, CL25022 |
Dilution | WB=1:500-2000,Elisa=1:500-1000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:50-200,IEM=1:20-200,IGS=1:20-200,GICA=1:20-200, |
Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
Name | MMADHC (HGNC:25221) |
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Synonyms | C2orf25, CL25022 |
Function | Involved in cobalamin metabolism and trafficking (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) (PubMed:18385497, PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510). |
Cellular Location | Cytoplasm. Mitochondrion |
Tissue Location | Widely expressed at high levels. |
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