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CRPPA Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | A4D126 |
| Other Accession | NP_001094896.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 49873 Da |
| Antigen Region | 400-429 aa |
| Gene ID | 729920 |
|---|---|
| Other Names | Isoprenoid synthase domain-containing protein, 277-, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein, ISPD |
| Target/Specificity | This CRPPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-429 amino acids from the C-terminal region of human CRPPA. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CRPPA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CRPPA (HGNC:37276) |
|---|---|
| Function | Cytidylyltransferase required for protein O-linked mannosylation (PubMed:22522420, PubMed:22522421, PubMed:26687144, PubMed:26923585, PubMed:27130732, PubMed:27601598). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:26687144, PubMed:26923585, PubMed:27130732). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:26687144, PubMed:26923585, PubMed:27130732). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5- phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144). |
| Cellular Location | Cytoplasm, cytosol. |
| Tissue Location | Ubiquitously expressed, with high expression in brain. |
Research Areas
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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$ 150.00
$ 385.00
Cat# AP5961b
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