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Anti-c-Myc (pT58) Antibody
Rabbit polyclonal antibody to c-Myc (pT58)
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Application 
| WB, IP, IHC |
|---|---|
| Primary Accession | P01106 |
| Other Accession | P01108 |
| Reactivity | Human, Mouse, Rat, Zebrafish, Pig, Chicken, Bovine, SARS, Drosophila |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50565 Da |
| Gene ID | 4609 |
|---|---|
| Other Names | BHLHE39; Myc proto-oncogene protein; Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64 |
| Target/Specificity | Recognizes endogenous levels of c-Myc (pT58) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IP (1/10 - 1/100) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IP (1/10 - 1/100) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | MYC |
|---|---|
| Synonyms | BHLHE39 |
| Function | Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). |
| Cellular Location | Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus. Cytoplasm |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human c-Myc. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP59629
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