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Anti-G3BP2 Antibody
Rabbit polyclonal antibody to G3BP2
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IP |
|---|---|
| Primary Accession | Q9UN86 |
| Other Accession | P97379 |
| Reactivity | Human, Mouse, Rat, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 54121 Da |
| Gene ID | 9908 |
|---|---|
| Other Names | KIAA0660; Ras GTPase-activating protein-binding protein 2; G3BP-2; GAP SH3 domain-binding protein 2 |
| Target/Specificity | Recognizes endogenous levels of G3BP2 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IP (1/10 - 1/100) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | G3BP2 {ECO:0000303|PubMed:23279204, ECO:0000312|HGNC:HGNC:30291} |
|---|---|
| Function | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling (PubMed:23279204, PubMed:32302570, PubMed:32302571, PubMed:32302572). Plays an essential role in stress granule formation (PubMed:27022092, PubMed:32302570, PubMed:32302571, PubMed:32302572). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PubMed:32302570, PubMed:32302571, PubMed:32302572). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (By similarity). |
| Cellular Location | Cytoplasm. Cytoplasm, Stress granule |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human G3BP2. The exact sequence is proprietary.
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