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Anti-MOV10L1 Antibody
Rabbit polyclonal antibody to MOV10L1
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- CITATIONS
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- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q9BXT6 |
| Other Accession | Q99MV5 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 135293 Da |
| Gene ID | 54456 |
|---|---|
| Other Names | Putative helicase Mov10l1; Moloney leukemia virus 10-like protein 1; MOV10-like protein 1 |
| Target/Specificity | Recognizes endogenous levels of MOV10L1 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | MOV10L1 (HGNC:7201) |
|---|---|
| Function | ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single- stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q99MV5}. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV5} |
| Tissue Location | [Isoform 1]: Specifically expressed in testis. |
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MOV10L1. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP60107
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