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Anti-AID Antibody
Rabbit polyclonal antibody to AID
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9GZX7 |
| Other Accession | Q9WVE0 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 23954 Da |
| Gene ID | 57379 |
|---|---|
| Other Names | AID; Single-stranded DNA cytosine deaminase; Activation-induced cytidine deaminase; Cytidine aminohydrolase |
| Target/Specificity | Recognizes endogenous levels of AID protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | AICDA |
|---|---|
| Synonyms | AID |
| Function | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894). |
| Cellular Location | Nucleus. Cytoplasm, cytosol Note=Predominantly cytosolic (PubMed:21385873). In the presence of MCM3AP/GANP, relocalizes to the nucleus (By similarity) {ECO:0000250|UniProtKB:Q9WVE0, ECO:0000269|PubMed:21385873} |
| Tissue Location | Strongly expressed in lymph nodes and tonsils. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human AID. The exact sequence is proprietary.
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