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Anti-GPR116 Antibody
Rabbit polyclonal antibody to GPR116
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- BACKGROUND
Application 
| WB, IF/IC, IHC |
|---|---|
| Primary Accession | Q8IZF2 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 149457 Da |
| Gene ID | 221395 |
|---|---|
| Other Names | KIAA0758; Probable G-protein coupled receptor 116 |
| Target/Specificity | Recognizes endogenous levels of GPR116 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) IF/IC~~N/A IHC~~1:100~500 |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | ADGRF5 (HGNC:19030) |
|---|---|
| Synonyms | GPR116, KIAA0758 |
| Function | Adhesion G protein-coupled receptor (PubMed:28570277). In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis (PubMed:28570277). Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation (PubMed:28570277). In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump (By similarity). As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Also plays a role in sFNDC4-induced decrease of local inflammation in white adipose tissue (PubMed:34016966). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in lung endothelial cells and in alveolar type II (ATII) cells (at protein level) (PubMed:23684610, PubMed:28570277). Expressed high levels in subcutaneous adipose tissue in lean individuals and at lower levels in visceral fat. Expression levels in subcutaneous adipose tissue drastically drop in obese individuals (PubMed:34016966). |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GPR116. The exact sequence is proprietary.
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$ 385.00
$ 195.00
Cat# AP60174
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