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Anti-CLN5 Antibody
Rabbit polyclonal antibody to CLN5
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O75503 |
| Other Accession | Q3UMW8 |
| Reactivity | Human, Mouse, Rat, Bovine, SARS |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 41497 Da |
| Gene ID | 1203 |
|---|---|
| Other Names | Ceroid-lipofuscinosis neuronal protein 5; Protein CLN5 |
| Target/Specificity | Recognizes endogenous levels of CLN5 protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CLN5 |
|---|---|
| Synonyms | BMPS {ECO:0000303|PubMed:37708259} |
| Function | [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG) (PubMed:37708259). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis (PubMed:37708259). Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths (PubMed:37708259). Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane (PubMed:22431521). Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane (PubMed:22431521). |
| Cellular Location | [Bis(monoacylglycero)phosphate synthase CLN5, secreted form]: Lysosome |
| Tissue Location | Ubiquitous.. |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CLN5. The exact sequence is proprietary.
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$ 385.00
$ 195.00
Cat# AP60443
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