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Anti-Adenylate Kinase 6 Antibody
Rabbit polyclonal antibody to Adenylate Kinase 6
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Application 
| WB, IF/IC, IHC |
|---|---|
| Primary Accession | Q9Y3D8 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 20061 Da |
| Gene ID | 102157402 |
|---|---|
| Other Names | CINAP; Adenylate kinase isoenzyme 6; AK6; Adrenal gland protein AD-004; Coilin-interacting nuclear ATPase protein; hCINAP; Dual activity adenylate kinase/ATPase; AK/ATPase |
| Target/Specificity | Recognizes endogenous levels of Adenylate Kinase 6 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/IC (1/100 - 1/500) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | AK6 {ECO:0000255|HAMAP-Rule:MF_03173} |
|---|---|
| Function | Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity (PubMed:15630091). Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation (PubMed:27477389). While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit (By similarity). Its NMP activity may have a role in nuclear energy homeostasis. AMP and dAMP are the preferred substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May be involved in regulation of Cajal body (CB) formation (PubMed:15630091). |
| Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03173}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03173}. Nucleus, Cajal body {ECO:0000255|HAMAP-Rule:MF_03173}. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli Detected in Cajal bodies but not in all cells. {ECO:0000255|HAMAP- Rule:MF_03173} |
| Tissue Location | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, chorionic villi and the central nervous system. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Adenylate Kinase 6. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP60736
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