Anti-MINPP1 Antibody
Rabbit polyclonal antibody to MINPP1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC |
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Primary Accession | Q9UNW1 |
Other Accession | Q9Z2L6 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 55051 Da |
Gene ID | 9562 |
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Other Names | MIPP; Multiple inositol polyphosphate phosphatase 1; 2, 3-bisphosphoglycerate 3-phosphatase; 2, 3-BPG phosphatase; Inositol (1, 3, 4, 5)-tetrakisphosphate 3-phosphatase; Ins(1, 3, 4, 5)P(4) 3-phosphatase |
Target/Specificity | Recognizes endogenous levels of MINPP1 protein. |
Dilution | WB~~WB (1/500 - 1/1000), IH (1/100 - 1/200) IH~~WB (1/500 - 1/1000), IH (1/100 - 1/200) |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | MINPP1 (HGNC:7102) |
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Function | Multiple inositol polyphosphate phosphatase that hydrolyzes 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (InsP5[2OH]) and 1D-myo- inositol hexakisphosphate (InsP6) to a range of less phosphorylated inositol phosphates. This regulates the availability of these various small molecule second messengers and metal chelators which control many aspects of cell physiology (PubMed:36589890, PubMed:33257696). Has a weak in vitro activity towards 1D-myo-inositol 1,4,5-trisphosphate which is unlikely to be physiologically relevant (PubMed:36589890). By regulating intracellular inositol polyphosphates pools, which act as metal chelators, it may control the availability of intracellular calcium and iron, which are important for proper neuronal development and homeostasis (PubMed:33257696). May have a dual substrate specificity, and function as a 2,3-bisphosphoglycerate 3-phosphatase hydrolyzing 2,3-bisphosphoglycerate to 2-phosphoglycerate. 2,3- bisphosphoglycerate (BPG) is formed as part of the Rapoport-Luebering glycolytic bypass and is a regulator of systemic oxygen homeostasis as the major allosteric effector of hemoglobin (PubMed:18413611). |
Cellular Location | Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O35217}. Secreted Cell membrane {ECO:0000250|UniProtKB:Q9Z2L6}. Note=Also associated with the plasma membrane in erythrocytes. {ECO:0000250|UniProtKB:Q9Z2L6} |
Tissue Location | Widely expressed with highest levels in kidney, liver, cerebellum and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MINPP1. The exact sequence is proprietary.
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