Anti-TRIM59 Antibody
Rabbit polyclonal antibody to TRIM59
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IF/IC, IHC |
---|---|
Primary Accession | Q8IWR1 |
Other Accession | Q922Y2 |
Reactivity | Human, Mouse, Rat, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 47114 Da |
Gene ID | 286827 |
---|---|
Other Names | RNF104; TRIM57; TSBF1; Tripartite motif-containing protein 59; RING finger protein 104; Tumor suppressor TSBF-1 |
Target/Specificity | Recognizes endogenous levels of TRIM59 protein. |
Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/100), IF/IC (1/100 - 1/500) IH~~WB (1/500 - 1/1000), IH (1/50 - 1/100), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IH (1/50 - 1/100), IF/IC (1/100 - 1/500) |
Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | TRIM59 |
---|---|
Synonyms | RNF104, TRIM57, TSBF1 |
Function | E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:30231667). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1 (PubMed:30231667). On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation (PubMed:30231667). Acts also as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'- linked ubiquitination (By similarity). |
Cellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TRIM59. The exact sequence is proprietary.
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