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Anti-RNF144B Antibody
Rabbit polyclonal antibody to RNF144B
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- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q7Z419 |
| Other Accession | Q8BKD6 |
| Reactivity | Human, Mouse, Rat, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33697 Da |
| Gene ID | 255488 |
|---|---|
| Other Names | IBRDC2; P53RFP; E3 ubiquitin-protein ligase RNF144B; IBR domain-containing protein 2; RING finger protein 144B; p53-inducible RING finger protein |
| Target/Specificity | Recognizes endogenous levels of RNF144B protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | RNF144B |
|---|---|
| Synonyms | IBRDC2, P53RFP |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin- dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se. |
| Cellular Location | Mitochondrion membrane; Single-pass membrane protein. Cytoplasm Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation |
| Tissue Location | Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human RNF144B. The exact sequence is proprietary.
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