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Anti-EPHA8 (pY615) Antibody
Rabbit polyclonal antibody to EPHA8 (pY615)
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Application 
| WB |
|---|---|
| Primary Accession | P29322 |
| Other Accession | O09127 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 111003 Da |
| Gene ID | 2046 |
|---|---|
| Other Names | EEK; HEK3; KIAA1459; Ephrin type-A receptor 8; EPH- and ELK-related kinase; EPH-like kinase 3; EK3; hEK3; Tyrosine-protein kinase receptor EEK |
| Target/Specificity | Recognizes endogenous levels of EPHA8 (pY615) protein. |
| Dilution | WB~~WB (1/500 - 1/1000) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | EPHA8 |
|---|---|
| Synonyms | EEK, HEK3, KIAA1459 |
| Function | Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:O09127}; Single-pass type I membrane protein. Cell projection {ECO:0000250|UniProtKB:O09127}. Early endosome membrane {ECO:0000250|UniProtKB:O09127}. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes {ECO:0000250|UniProtKB:O09127} |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human EPHA8. The exact sequence is proprietary.
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$ 385.00
$ 195.00
Cat# AP61091
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