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Anti-Beta-NaCH (pT615) Antibody
Rabbit polyclonal antibody to Beta-NaCH (pT615)
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Application 
| WB, IF/IC, IHC |
|---|---|
| Primary Accession | P51168 |
| Other Accession | Q9WU38 |
| Reactivity | Human, Mouse, Rat, Bovine, SARS, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 72659 Da |
| Gene ID | 6338 |
|---|---|
| Other Names | Amiloride-sensitive sodium channel subunit beta; Beta-NaCH; Epithelial Na(+) channel subunit beta; Beta-ENaC; ENaCB; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB |
| Target/Specificity | Recognizes endogenous levels of Beta-NaCH (pT615) protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/200), IF/IC (1/100 - 1/500) IF/IC~~N/A IHC~~1:100~500 |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SCNN1B {ECO:0000303|PubMed:7490094, ECO:0000312|HGNC:HGNC:10600} |
|---|---|
| Function | This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7762608, PubMed:9792722). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24124190). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247). Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:24124190). |
| Cellular Location | Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P37090}; Multi-pass membrane protein |
| Tissue Location | Detected in placenta, lung and kidney (PubMed:7762608). Expressed in kidney (at protein level) (PubMed:22207244). |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Beta-NaCH (pT615). The exact sequence is proprietary.
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$ 385.00
$ 195.00
Cat# AP61171
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