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> home > Products > Primary Antibodies > Antibody Collections > GPCR Antibodies > Anti-Frizzled 1 Antibody
Anti-Frizzled 1 Antibody
Rabbit polyclonal antibody to Frizzled 1
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, IF/IC |
|---|---|
| Primary Accession | Q9UP38 |
| Other Accession | O70421 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 71158 Da |
| Gene ID | 8321 |
|---|---|
| Other Names | Frizzled-1; Fz-1; hFz1; FzE1 |
| Target/Specificity | Recognizes endogenous levels of Frizzled 1 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IF/IC (1/100 - 1/500) IF~~WB (1/500 - 1/1000), IF/IC (1/100 - 1/500) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | FZD1 |
|---|---|
| Function | Receptor for Wnt proteins (PubMed:10557084). Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (PubMed:10557084). Contradictory results showing activation by WNT7B have been described for mouse (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:10557084). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:10557084). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in adult heart, placenta, lung, kidney, pancreas, prostate, and ovary and in fetal lung and kidney |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Frizzled 1. The exact sequence is proprietary.
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$ 350.00
$ 175.00
Cat# AP61230
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