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Anti-CDK5RAP1 Antibody
Rabbit polyclonal antibody to CDK5RAP1
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- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q96SZ6 |
| Other Accession | Q8BTW8 |
| Reactivity | Human, Mouse, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 67689 Da |
| Gene ID | 51654 |
|---|---|
| Other Names | C20orf34; CDK5 regulatory subunit-associated protein 1; CDK5 activator-binding protein C42 |
| Target/Specificity | Recognizes endogenous levels of CDK5RAP1 protein. |
| Dilution | WB~~WB (1/500 - 1/1000), IH (1/50 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CDK5RAP1 (HGNC:15880) |
|---|---|
| Synonyms | C20orf34 |
| Function | Methylthiotransferase that catalyzes the conversion of N6- (dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease (PubMed:25738458). |
| Cellular Location | Mitochondrion. |
| Tissue Location | Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas (PubMed:10721722). Expressed in neurons of central nervous tissue (PubMed:10721722, PubMed:11882646) [Isoform 6]: High expression in placenta and lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CDK5RAP1. The exact sequence is proprietary.
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