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Anti-p21 Antibody
Rabbit polyclonal antibody to p21
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- BACKGROUND
Application 
| WB, IHC |
|---|---|
| Primary Accession | P38936 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 18119 Da |
| Gene ID | 1026 |
|---|---|
| Other Names | CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21 |
| Target/Specificity | Recognizes endogenous levels of p21 protein. |
| Dilution | WB~~WB (1/1000 - 1/2000), IH (1/100 - 1/200) IH~~WB (1/1000 - 1/2000), IH (1/100 - 1/200) |
| Format | Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CDKN1A (HGNC:1784) |
|---|---|
| Function | Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed:9106657). Involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Also involved in p53-independent DNA damage-induced G2 arrest mediated by CREB3L1 in astrocytes and osteoblasts (By similarity). Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed in all adult tissues, with 5-fold lower levels observed in the brain |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Recombinant protein corresponding to human p21.
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$ 350.00
$ 175.00
Cat# AP61602
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