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Anti-TPSAB1 Antibody
Mouse monoclonal antibody to TPSAB1
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Application 
| IHC |
|---|---|
| Primary Accession | Q15661 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Calculated MW | 30515 Da |
| Gene ID | 7177 |
|---|---|
| Other Names | TPS1; TPS2; TPSB1; Tryptase alpha/beta-1; Tryptase-1; Tryptase I; Tryptase alpha-1 |
| Target/Specificity | Recognizes endogenous levels of TPSAB1 protein. |
| Dilution | IH~~IH (1/100 - 1/300) IF~~IH (1/100 - 1/300) IP~~IH (1/100 - 1/300) FC~~IH (1/100 - 1/300) CHIP~~IH (1/100 - 1/300) |
| Format | Mouse IgG1. Liquid in PBS containing 50% glycerol, 0.2% BSA and 0.09% (W/V) sodium azide. |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TPSAB1 |
|---|---|
| Synonyms | TPS1, TPS2, TPSB1 |
| Function | Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates (PubMed:18854315). |
| Cellular Location | Secreted. Note=Released from the secretory granules upon mast cell activation. |
| Tissue Location | Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and skin; in these tissues, isoform 1 is predominant. Isoform 2 is expressed in aorta, spleen, and breast tumor, with highest levels in the endothelial cells of some blood vessels surrounding the aorta, as well as those surrounding the tumor and low levels, if any, in mast cells (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
KLH-conjugated synthetic peptide encompassing a sequence within human TPSAB1. The exact sequence is proprietary.
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