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SOX30 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O94993 |
| Other Accession | Q8CGW4, Q8WNV5 |
| Reactivity | Human |
| Predicted | Monkey, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 81854 Da |
| Antigen Region | 373-403 aa |
| Gene ID | 11063 |
|---|---|
| Other Names | Transcription factor SOX-30, SOX30 |
| Target/Specificity | This SOX30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-403 amino acids from the Central region of human SOX30. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SOX30 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SOX30 |
|---|---|
| Function | Acts both as a transcriptional activator and a repressor (PubMed:10359848, PubMed:29739711). Binds to the DNA sequence 5'-ACAAT- 3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711). |
| Cellular Location | Nucleus. Cytoplasm Note=Enriched at the chromocenter. {ECO:0000250|UniProtKB:Q8CGW4} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SOX30 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. SOX30 may act as a transcriptional regulator after forming a protein complex with other proteins, and it may be involved in the differentiation of developing male germ cells.
References
Koopman,P., Gene 328, 177-186 (2004)
Bullejos,M., Genetica 110 (2), 157-162 (2000)
Osaki,E., Nucleic Acids Res. 27 (12), 2503-2510 (1999)
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